Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

doi:10.1165/rcmb.2013-0238OC

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Article

Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

American journal of respiratory cell and molecular biology - 1 Aug 2014

Tejera Paula, O'Mahony D Shane, Owen Caroline A, Wei Yongyue, Wang Zhaoxi, Gupta Kushagra, Su Li, Villar Jesus, Wurfel Mark, Christiani David C

Abstract excerpt

Elafin (peptidase inhibitor 3 [PI3]) and its biologically active precursor, pre-elafin, are neutrophil serine proteinase inhibitors with an important role in preventing excessive tissue injury during inflammatory events. Recently, we reported an association between single-nucleotide polymorphism (SNP) rs2664581 in the PI3 gene, increased risk of acute respiratory distress syndrome (ARDS) and pre-elafin...

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PMID: 24617927
DOI: 10.1165/rcmb.2013-0238OC
PMCID: PMC4148037

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