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Article

A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2011

Jégot Gwenhael, Derache Chrystelle, Castella Sandrine, Lahouassa Hichem, Pitois Elodie, Jourdan Marie Lise, Remold-O'Donnell Eileen, Kellenberger Christine, Gauthier Francis, Korkmaz Brice

Abstract excerpt

The physiological and pathological functions of proteinase 3 (PR3) are not well understood due to its close similarity to human neutrophil elastase (HNE) and the lack of a specific inhibitor. Based on structural analysis of the active sites of PR3 and HNE, we generated mutants derived from the polyvalent inhibitor SerpinB1 (monocyte/neutrophil elastase inhibitor) that specifically inhibit PR3 and that differ from...

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PMID: 21670065
DOI: 10.1096/fj.10-176552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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