Article

Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding

2023-11-11

Abstract excerpt

Neutrophil proteinase 3 (PR3) is an important drug target for inflammatory lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Drug discovery efforts targeting PR3 require active enzyme for in vitro characterization, such as inhibitor screening, enzymatic assays, and structural studies. Recombinant expression of active PR3 overcomes the need for enzyme supplies from human blood and in...

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Literature Corpus work: 33a804db-1f4d-5c46-be22-2191374933d1
DOI: 10.1101/2023.11.10.566610

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