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Article

Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair.

International journal of cancer - 1 Oct 2014

Yee Ko Josephine Mun, Dai Wei, Wun Wong Elibe Hiu, Kwong Dora, Tong Ng Wai, Lee Anne, Kai Cheong Ngan Roger, Chung Yau Chun, Tung Stewart, Li Lung Maria

Abstract excerpt

The genetic etiology of nasopharyngeal carcinoma (NPC) and mechanisms for inherited susceptibility remain unclear. To examine genetic risk factors for NPC, we hypothesized that heritable risk is attributable to cumulative effects of multiple common low-risk variants. With the premise that individual SNPs only confer subtle effects for cancer risk, a multigenic pathway-based approach was used to systematically...

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Source

Identifiers

PMID: 24615621
DOI: 10.1002/ijc.28802

Genes

TERT
BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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