Article
Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai.
International journal of cancer - 15 Jul 2014
Corral Roman, Lewinger Juan Pablo, Van Den Berg David, Joshi Amit D, Yuan Jian-Min, Gago-Dominguez Manuela, Cortessis Victoria K, Pike Malcolm C, Conti David V, Thomas Duncan C, Edlund Christopher K, Gao Yu-Tang, Xiang Yong-Bing, Zhang Wei, Su Yu-Chen, Stern Mariana C
Abstract excerpt
Tobacco smoking is a bladder cancer risk factor and a source of carcinogens that induce DNA damage to urothelial cells. Using data and samples from 988 cases and 1,004 controls enrolled in the Los Angeles County Bladder Cancer Study and the Shanghai Bladder Cancer Study, we investigated associations between bladder cancer risk and 632 tagSNPs that comprehensively capture genetic variation in 28 DNA repair genes...
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