Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.

doi:10.1093/carcin/bgt094

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Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.

Carcinogenesis - 1 Jul 2013

Li Wen-Qing, Hu Nan, Hyland Paula L, Gao Ying, Wang Zhao-Ming, Yu Kai, Su Hua, Wang Chao-Yu, Wang Le-Min, Chanock Stephen J, Burdett Laurie, Ding Ti, Qiao You-Lin, Fan Jin-Hu, Wang Yuan, Xu Yi, Shi Jian-Xin, Gu Fangyi, Wheeler William, Xiong Xiao-Qin, Giffen Carol, Tucker Margaret A, Dawsey Sanford M, Freedman Neal D, Abnet Christian C, Goldstein Alisa M, Taylor Philip R

Abstract excerpt

The DNA repair pathways help to maintain genomic integrity and therefore genetic variation in the pathways could affect the propensity to develop cancer. Selected germline single nucleotide polymorphisms (SNPs) in the pathways have been associated with esophageal cancer and gastric cancer (GC) but few studies have comprehensively examined the pathway genes. We aimed to investigate associations between DNA repair...

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PMID: 23504502
DOI: 10.1093/carcin/bgt094
PMCID: PMC3697889

Genes

BRCA1
CHEK2
CLK2
FANCE
FEN1
MPG
POLE
POLQ
SMUG1
TDG

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