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Article

Inhibition of dopamine signaling suppresses cGMP accumulation in rd1 retinal organ cultures.

Neuroreport - 28 May 2014

Zhang Ju, Richmond Angela M, Ogilvie Judith M

Abstract excerpt

The rd1 mouse is a model of retinitis pigmentosa, an inherited photoreceptor neurodegenerative disease. In rd1 retina, early onset rod degeneration is caused by a Pde6b mutation that leads to high levels of intracellular cyclic guanosine monophosphate (cGMP). Cyclic nucleotide-gated ion channels (CNGCs), necessary for phototransduction, are regulated by cGMP. We have previously demonstrated that inhibition of...

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Share to Cyclic GMP
Share to Cyclic Nucleotide-Gated Cation Channels
Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Organ Culture Techniques

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Share to Photoreceptor Cells, Vertebrate

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Source

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Identifiers

PMID: 24614363
DOI: 10.1097/WNR.0000000000000145
PMCID: PMC4275426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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