Article
Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms.
Cell death & disease - 7 Feb 2013
Sahaboglu A, Paquet-Durand O, Dietter J, Dengler K, Bernhard-Kurz S, Ekström P Ar, Hitzmann B, Ueffing M, Paquet-Durand F
Abstract excerpt
For most neurodegenerative diseases the precise duration of an individual cell's death is unknown, which is an obstacle when counteractive measures are being considered. To address this, we used the rd1 mouse model for retinal neurodegeneration, characterized by phosphodiesterase-6 (PDE6) dysfunc...
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