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Article

Retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGA1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2021

Liu Yang, Wang Yafang, Xiao Yushu, Li Xiaomeng, Ruan Shang, Luo Xueting, Wan Xiaoling, Wang Fenghua, Sun Xiaodong

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels are important mediators in the transduction pathways of rod and cone photoreceptors. Native CNG channels are heterotetramers composed of homologous A and B subunits. Biallelic mutations in CNGA1 or CNGB1 genes result in autosomal recessive retinitis pigmentosa (RP). To investigate the pathogenic mechanism of CNG channel-associated retinal degeneration, we developed a mouse...

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PMID: 34418172
DOI: 10.1096/fj.202101004R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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