Article
A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 1998
Semple-Rowland S L, Lee N R, Van Hooser J P, Palczewski K, Baehr W
Abstract excerpt
The retinas of the retinal degeneration (rd) chicken are fully developed and possess normal morphology at hatching but fail to respond to light stimulation. Analyses of retinal cGMP, the internal messenger of phototransduction, show that the amount of cGMP in predegenerate, fully developed rd/rd photoreceptors is 5-10 times less than that seen in normal photoreceptor cells. We show that the low levels of cGMP in...
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