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Article

PKG activity causes photoreceptor cell death in two retinitis pigmentosa models

5 Dec 2008

Abstract excerpt

Photoreceptor degeneration in retinitis pigmentosa is one of the leading causes of hereditary blindness in the developed world. Although causative genetic mutations have been elucidated in many cases, the underlying neuronal degeneration mechanisms are still unknown. Here, we show that activation of cGMP-dependent protein kinase (PKG) hallmarks photoreceptor degeneration in rd1 and rd2 human homologous mouse...

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PMID: 19187097
DOI: 10.1111/j.1471-4159.2008.05822.x

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