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cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology.

Experimental eye research - 1 Nov 2021

Zhou Jiaming, Rasmussen Michel, Ekström Per

Abstract excerpt

Retinitis Pigmentosa represents a group of genetic disorders that cause progressive vision loss via degeneration of photoreceptors, but there is in principle no treatment available. For any therapy development, a deeper comprehension of the disease-leading mechanism(s) at the molecular level is needed. Here we focused on the cGMP-PKG system, which has been suggested to be a driver in several models of the...

Topics

Animals
Cells, Cultured
Cyclic GMP
DNA
DNA Mutational Analysis
Disease Models, Animal
Mice
Mice, Inbred C3H
Mutation
Protein Kinases
Retina
Retinal Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinitis Pigmentosa

Signal Transduction

Transcriptome

Source

Identifiers

PMID: 34478738
DOI: 10.1016/j.exer.2021.108752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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