RD Genes Associated with High Photoreceptor cGMP-Levels (Mini-Review).

Abstract excerpt

Many RD-causing mutations lead to a dysregulation of cyclic guanosine monophosphate (cGMP), making cGMP signalling a prime target for the development of new treatment approaches. We showed previously that an analogue of cGMP, which inhibited cGMP signalling targets, increased photoreceptor viability in three rodent RD models carrying different genetic defects, in different RD genes. This raises the question of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cyclic GMP
• Share to Mutation
• Share to Photoreceptor Cells, Vertebrate