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Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches.

Journal of neurogenetics - 1 Sept 2017

Iribarne Maria, Masai Ichiro

Abstract excerpt

Zebrafish are an excellent animal model for research on vertebrate development and human diseases. Sophisticated genetic tools including large-scale mutagenesis methodology make zebrafish useful for studying neuronal degenerative diseases. Here, we review zebrafish models of inherited ophthalmic diseases, focusing on cGMP metabolism in photoreceptors. cGMP is the second messenger of phototransduction, and...

Topics

Animals
Cyclic GMP
Cyclic Nucleotide Phosphodiesterases, Type 6
Disease Models, Animal
Humans
Mice
Mice, Mutant Strains
Mutation
Photoreceptor Cells, Vertebrate
Retina
Retinal Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vision, Ocular

Zebrafish

Source

Identifiers

PMID: 28812418
DOI: 10.1080/01677063.2017.1358268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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