Article
Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells.
Laboratory investigation; a journal of technical methods and pathology - 1 May 2014
Shen Xiao Z, Okwan-Duodu Derick, Blackwell Wendell-Lamar, Ong Frank S, Janjulia Tea, Bernstein Ellen A, Fuchs Sebastien, Alkan Serhan, Bernstein Kenneth E
Abstract excerpt
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells which accumulate in cancer, infection and chronic inflammation. These cells suppress T-cell function and the immune response. Angiotensin-converting enzyme (ACE) is a peptidase that is now known to regulate aspects of myelopoiesis. Here, we show that ACE expression correlates with myeloid maturation in vitro. Forced...
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