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Article

Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus.

The Journal of biological chemistry - 10 Dec 2010

Okwan-Duodu Derick, Datta Vivekanand, Shen Xiao Z, Goodridge Helen S, Bernstein Ellen A, Fuchs Sebastien, Liu George Y, Bernstein Kenneth E

Abstract excerpt

Gene targeting in ES cells was used to substitute control of angiotensin converting enzyme (ACE) expression from the endogenous promoter to the mouse c-fms promoter. The result is an animal model called ACE 10/10 in which ACE is overexpressed by monocytes, macrophages, and other myelomonocytic lineage cells. To study the immune response of these mice to bacterial infection, we challenged them with Listeria...

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Identifiers

PMID: 20937811
DOI: 10.1074/jbc.M110.163782
PMCID: PMC2998083

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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