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Article

COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.

Cancer research - 1 Apr 2011

Fujita Mitsugu, Kohanbash Gary, Fellows-Mayle Wendy, Hamilton Ronald L, Komohara Yoshihiro, Decker Stacy A, Ohlfest John R, Okada Hideho

Abstract excerpt

Epidemiologic studies have highlighted associations between the regular use of nonsteroidal anti-inflammatory drugs (NSAID) and reduced glioma risks in humans. Most NSAIDs function as COX-2 inhibitors that prevent production of prostaglandin E₂ (PGE₂). Because PGE₂ induces expansion of myeloid-derived suppressor cells (MDSC), we hypothesized that COX-2 blockade would suppress gliomagenesis by inhibiting MDSC...

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Source

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Identifiers

PMID: 21324923
DOI: 10.1158/0008-5472.CAN-10-3055
PMCID: PMC3075086

Genes

CXCL10
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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