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Article

Myeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune disease.

Journal of leukocyte biology - 1 Mar 2015

Crook Kristen R, Jin Mengyao, Weeks Michael F, Rampersad Rishi R, Baldi Robert M, Glekas Amy S, Shen Yajuan, Esserman Denise A, Little Paul, Schwartz Todd A, Liu Peng

Abstract excerpt

MDSCs are a heterogeneous group of myeloid cells that suppress T cell activity in cancer and autoimmune disease. The effect of MDSCs on B cell function is not clear. Using the CIA model of autoimmune disease, we found an increase in M-MDSCs in the periphery of WT mice with CIA compared with naïve mice. These MDSCs were absent from the periphery of CCR2(-/-) mice that developed exacerbated disease. M-MDSCs,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25583578
DOI: 10.1189/jlb.4A0314-139R
PMCID: PMC4338846

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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