Article
Control of dendritic cell differentiation by angiotensin II.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2003
Nahmod Karen A, Vermeulen Monica E, Raiden Silvina, Salamone Gabriela, Gamberale Romina, Fernández-Calotti Paula, Alvarez Azucena, Nahmod Victor, Giordano Mirta, Geffner Jorge R
Abstract excerpt
Here we analyze the role of the angiotensinergic system in the differentiation of dendritic cells (DC). We found that human monocytes produce angiotensin II (AII) and express AT1 and AT2 receptors for AII. DC differentiated from human monocytes in the presence of AT1 receptor antagonists losartan or candesartan show very low levels of CD1a expression and poor endocytic and allostimulatory activities. By contrast,...
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