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Article

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

1 Mar 2014

Abstract excerpt

BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180. Based on data from yeast, we hypothesized that BAF180 may prevent tumorigenesis by promoting cohesion. Here, we show BAF180 is required for centromeric cohesion in mouse and human cells. Mutations...

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PMID: 24613357
DOI: 10.1016/j.celrep.2014.02.012

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