Article

Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice

2018-09-12

Abstract excerpt

CENP-F is a large, microtubule-binding protein that regulates multiple cellular processes including chromosome segregation and mitochondrial trafficking at cytokinesis. This multiplicity of function is mediated through the binding of various partners, like Bub1 at the kinetochore and Miro at mito-chondria. Due to the multifunctionality of CENP-F, the cellular phenotypes observed upon its depletion are difficult to...

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Literature Corpus work: d503befa-3f90-55e1-ba74-a27e93372bad
DOI: 10.1101/415315

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