A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity.

doi:10.1093/cercor/bhy189

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Article

A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity.

Cerebral cortex (New York, N.Y. : 1991) - 22 Jul 2019

Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, Kikuchi Yoshie, Ono Chiaki, Yu Zhiqian, Nouchi Rui, Yokoyama Ryoichi, Kotozaki Yuka, Nakagawa Seishu, Sekiguchi Atsushi, Iizuka Kunio, Hanawa Sugiko, Araki Tsuyoshi, Miyauchi Carlos Makoto, Sakaki Kohei, Nozawa Takayuki, Ikeda Shigeyuki, Yokota Susumu, Magistro Daniele, Sassa Yuko, Kawashima Ryuta

Abstract excerpt

Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons,...

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Identifiers

PMID: 30124797
DOI: 10.1093/cercor/bhy189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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