Article
Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.
The Journal of clinical endocrinology and metabolism - 1 Jul 2019
De Rosa Maria Caterina, Chesi Alessandra, McCormack Shana, Zhou Justin, Weaver Benjamin, McDonald Molly, Christensen Sinead, Liimatta Kalle, Rosenbaum Michael, Hakonarson Hakon, Doege Claudia A, Grant Struan F A, Hirschhorn Joel N, Thaker Vidhu V
Abstract excerpt
CONTEXT: Mutations in melanocortin receptor (MC4R) are the most common cause of monogenic obesity in children of European ancestry, but little is known about their prevalence in children from the minority populations in the United States. OBJECTIVE: This study aims to identify the prevalence of MC4R mutations in children with severe early-onset obesity of African American or Latino ancestry. DESIGN AND SETTING:...
Topics
- Adolescent
- Black or African American
- Age of Onset
- Child
- Child, Preschool
- Female
- Hispanic or Latino
- Humans
- Infant
- Male