Article
Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children.
Obesity (Silver Spring, Md.) - 1 Mar 2011
van den Berg Linda, van Beekum Olivier, Heutink Peter, Felius Bram A, van de Heijning Monique P M, Strijbis Stefan, van Spaendonk Rosalina, Piancatelli Daniela, Garner Keith M, El Aouad Rajae, Sistermans Erik, Adan Roger A H, Delemarre-van de Waal Henriette A
Abstract excerpt
The most common monogenic form of obesity is caused by mutations in the gene encoding the melanocortin-4 receptor (MC4R). We have screened the MC4R coding sequence in 291 patients of a Dutch outpatient pediatric obesity clinic. We analyzed the minimal promoter region of the gene in a random subgroup of 217 children. Our aims were (i) to determine the frequency of MC4R mutations in a cohort of Dutch clinically...
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