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Article

Identification of minority resistance mutations in the HIV-1 integrase coding region using next generation sequencing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2015

Fonager Jannik, Larsson Jonas T, Hussing Christian, Neess Engsig Frederik, Nielsen Claus, Fischer Thea Kølsen

Abstract excerpt

BACKGROUND: The current widely applied standard method to screen for HIV-1 genotypic resistance is based on Sanger population sequencing (Sseq), which does not allow for the identification of minority variants (MVs) below the limit of detection for the Sseq-method in patients receiving integrase strand-transfer inhibitors (INSTI). Next generation sequencing (NGS) has facilitated the detection of MVs at a much...

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PMID: 26587787
DOI: 10.1016/j.jcv.2015.11.009

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