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Article

A functionally significant polymorphism in ID3 is associated with human coronary pathology.

PloS one - 1 Jan 2014

Manichaikul Ani, Rich Stephen S, Perry Heather, Yeboah Joseph, Law Michelle, Davis Molly, Parker Matthew, Ragosta Michael, Connelly Jessica J, McNamara Coleen A, Taylor Angela M

Abstract excerpt

AIMS: We previously identified association between the ID3 SNP rs11574 and carotid intima-media thickness in the Diabetes Heart Study, a predominantly White diabetic population. The nonsynonymous SNP rs11574 results in an amino acid substitution in the C-terminal region of ID3, attenuating the dominant negative function of ID3 as an inhibitor of basic HLH factor E12-mediated transcription. In the current...

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Identifiers

PMID: 24603695
DOI: 10.1371/journal.pone.0090222
PMCID: PMC3946163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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