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Article

Identifying functional non-coding variants in APOA5/A4/C3/A1 gene cluster associated with coronary heart disease.

Journal of molecular and cellular cardiology - 1 Jul 2020

Cui Guanglin, Tian Min, Hu Senlin, Wang Yan, Wang Dao Wen

Abstract excerpt

Recent genome-wide association studies identified several polymorphisms in the APOA5/A4/C3/A1 gene cluster influencing lipids level and risk of coronary heart disease (CHD). However, few studies explored the molecular mechanism. The purposes of this study were to fine-map noncoding region between APOA1 and APOC3 and then explore the clinical relevance in CHD and potential underlying mechanisms. In this study, a...

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PMID: 32437778
DOI: 10.1016/j.yjmcc.2020.05.003

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