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Article

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.

The Journal of clinical investigation - 1 Aug 2011

Weissglas-Volkov Daphna, Calkin Anna C, Tusie-Luna Teresa, Sinsheimer Janet S, Zelcer Noam, Riba Laura, Tino Ana Maria Vargas, Ordoñez-Sánchez Maria Luisa, Cruz-Bautista Ivette, Aguilar-Salinas Carlos A, Tontonoz Peter, Pajukanta Päivi

Abstract excerpt

Atherosclerotic cardiovascular disease (ASCVD) affects more than 1 in 3 American adults. Hypercholesterolemia is a major treatable risk factor for ASCVD, yet many individuals fail to reach target levels of LDL-cholesterol (LDL-C) through the use of statins and lifestyle changes. The E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also known as IDOL) is a recently identified regulator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21765216
DOI: 10.1172/JCI45504
PMCID: PMC3148733

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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