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Article

An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy.

PLoS genetics - 1 Mar 2014

Li Yun, Chen Jason A, Sears Renee L, Gao Fuying, Klein Eric D, Karydas Anna, Geschwind Michael D, Rosen Howard J, Boxer Adam L, Guo Weilong, Pellegrini Matteo, Horvath Steve, Miller Bruce L, Geschwind Daniel H, Coppola Giovanni

Abstract excerpt

Little is known about how changes in DNA methylation mediate risk for human diseases including dementia. Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia--progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD)--revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls. Remarkably, DMPs in PSP were clustered...

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Share to Chromosomes, Human, Pair 17
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Frontotemporal Dementia

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Share to Supranuclear Palsy, Progressive

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Identifiers

PMID: 24603599
DOI: 10.1371/journal.pgen.1004211
PMCID: PMC3945475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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