Back to search

Article

DNA methylation as a contributor to dysregulation of <i>STX6</i> and other frontotemporal lobar degeneration genetic risk-associated loci

2025-01-21

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) represents a spectrum of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders. The two major FTLD pathological subgroups are FTLD-TDP and FTLD-tau. While the majority of FTLD cases are sporadic, heterogeneity also exists within the familial cases, typically involving mutations in MAPT, GRN or C9orf72, which is not fully explained by known...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
17187bbb-881f-5d83-9b00-55f5ec28a0b6
DOI
10.1101/2025.01.21.634065
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DNA methylation as a contributor to dysregulation of <i>STX6</i> and other frontotemporal lobar degeneration genetic risk-associated lociDOI 10.1101/2025.01.21.634065
DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci.Semantic proximity
Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals <i>OTUD4</i> in shared dysregulated signatures across pathological subtypesSemantic proximity
Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1Semantic proximity
DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons From Alzheimers, Related Tauopathies and Genetic TauopathiesSemantic proximity
Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWASSemantic proximity
DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic TauopathiesSemantic proximity
Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort studySemantic proximity
Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.Semantic proximity
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: A cross-comparative investigationSemantic proximity
Integrative Epigenomic Landscape of Alzheimer’s Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with TauSemantic proximity
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases.Semantic proximity
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.Semantic proximity
Select a neighboring publication to make it the new centre.