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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

2021-10-07

Abstract excerpt

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available causal therapy, neuropathologically characterized by intraneuronal aggregates of misfolded α-synuclein. To explore the role of DNA methylation changes in PD and DLB pathogenesis, we performed an epigenome-wide association study (EWAS) of 322 postmortem frontal cortex samples and replicated resul...

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Literature Corpus work
2b334814-4ee5-522b-b42b-1af8dffd0f59
DOI
10.1101/2021.10.07.21264552
Open publication

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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathologyDOI 10.1101/2021.10.07.21264552
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