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Article

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2018

Smith Rebecca G, Hannon Eilis, De Jager Philip L, Chibnik Lori, Lott Simon J, Condliffe Daniel, Smith Adam R, Haroutunian Vahram, Troakes Claire, Al-Sarraj Safa, Bennett David A, Powell John, Lovestone Simon, Schalkwyk Leonard, Mill Jonathan, Lunnon Katie

Abstract excerpt

INTRODUCTION: Alzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain. METHODS: We performed an epigenome-wide association study to identify differential DNA methylation associated with neuropathology in prefrontal cortex and superior temporal gyrus samples from 147 individuals, replicating our findings in two independent data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29550519
DOI: 10.1016/j.jalz.2018.01.017
PMCID: PMC6438205

Genes

HOXA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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