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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

22 Aug 2022

Abstract excerpt

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy, neuropathologically characterized by intraneuronal aggregates of misfolded α-synuclein. To explore the role of DNA methylation changes in PD and DLB pathogenesis, we performed an epigenome-wide association study (EWAS) of 322 postmortem frontal cortex samples and...

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PMID: 35995800
DOI: 10.1038/s41467-022-32619-z

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