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Article

Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.

PLoS computational biology - 1 Mar 2014

Jilkine Alexandra, Gutenkunst Ryan N

Abstract excerpt

Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived cancer stem cells. It is unclear, however, whether cancer stem cells originate from normal stem cells or from dedifferentiated progenitor cells. To address this, we...

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Identifiers

PMID: 24603301
DOI: 10.1371/journal.pcbi.1003481
PMCID: PMC3945168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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