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Article

Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2.

European journal of clinical pharmacology - 1 May 2014

Ferrari Marco, Guasti Luigina, Maresca Andrea, Mirabile Mauro, Contini Sara, Grandi Anna Maria, Marino Franca, Cosentino Marco

Abstract excerpt

PURPOSE: Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved in statin disposition. METHODS: Patients with and without statin-induced elevated serum CK...

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Source

Identifiers

PMID: 24595600
DOI: 10.1007/s00228-014-1661-6

Genes

ABCB1
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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