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Article

The SLCO1B1*5 genetic variant is associated with statin-induced side effects.

Journal of the American College of Cardiology - 20 Oct 2009

Voora Deepak, Shah Svati H, Spasojevic Ivan, Ali Shazia, Reed Carol R, Salisbury Benjamin A, Ginsburg Geoffrey S

Abstract excerpt

OBJECTIVES: We sought to identify single nucleotide polymorphisms associated with mild statin-induced side effects. BACKGROUND: Statin-induced side effects can interfere with therapy. Single nucleotide polymorphisms in cytochrome P450 enzymes impair statin metabolism; the reduced function SLCO1B1*5 allele impairs statin clearance and is associated with simvastatin-induced myopathy with creatine kinase (CK)...

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Identifiers

PMID: 19833260
DOI: 10.1016/j.jacc.2009.04.053
PMCID: PMC3417133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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