Article

Genetic Polymorphisms in Drug Transporter Genes (ABCB1, OATP1B1) and Their Impact on Statin Pharmacokinetics and Myopathy Risk

2026-01-12

Abstract excerpt

<h4>Background: </h4> /Objectives: Interindividual variability in statin pharmacokinetics and susceptibility to statin-associated myopathy has been partly attributed to genetic variation in drug transporter genes. Polymorphisms in SLCO1B1 and ABCB1 influence statin disposition; however, their combined associations with systemic exposure and clinically relevant muscle toxicity remain incompletely characterized in r...

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Literature Corpus work: bc980890-2f2b-56a6-9aee-c8c5cda64ba1
DOI: 10.20944/preprints202601.0803.v1

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