SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink.

doi:10.1038/clpt.2013.161

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SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink.

Clinical pharmacology and therapeutics - 1 Dec 2013

Carr D F, O'Meara H, Jorgensen A L, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M

Abstract excerpt

This study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink, whether DNA could be obtained, and whether previously reported associations of statin myopathy with the SLCO1B1 c.521T>C and COQ2 rs4693075 polymorphisms could be replicated. Seventy-seven statin-induced myopathy patients (serum creatine phosphokinase (CPK)...

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PMID: 23942138
DOI: 10.1038/clpt.2013.161
PMCID: PMC3831180

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COQ2

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