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Article

Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1.

Pflugers Archiv : European journal of physiology - 1 Dec 2014

Rubino Rosa, Bezzerri Valentino, Favia Maria, Facchini Marcella, Tebon Maela, Singh Anurag Kumar, Riederer Brigitte, Seidler Ursula, Iannucci Antonio, Bragonzi Alessandra, Cabrini Giulio, Reshkin Stephan J, Tamanini Anna

Abstract excerpt

Pseudomonas aeruginosa infections of the airway cells decrease apical expression of both wild-type (wt) and F508del CFTR through the inhibition of apical endocytic recycling. CFTR endocytic recycling is known to be regulated by its interaction with PDZ domain containing proteins. Recent work has shown that the PDZ domain scaffolding protein NHERF1 finely regulates both wt and F508delCFTR membrane recycling. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24595473
DOI: 10.1007/s00424-014-1474-6

Genes

NHERF1
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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