Article
Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells.
The Journal of biological chemistry - 9 Dec 2005
Guerra Lorenzo, Fanelli Teresa, Favia Maria, Riccardi Stefania M, Busco Giovanni, Cardone Rosa Angela, Carrabino Salvatore, Weinman Edward J, Reshkin Stephan Joel, Conese Massimo, Casavola Valeria
Abstract excerpt
There is evidence that cystic fibrosis transmembrane conductance regulator (CFTR) interacting proteins play critical roles in the proper expression and function of CFTR. The Na(+)/H(+) exchanger regulatory factor isoform 1 (NHERF1) was the first identified CFTR-binding protein. Here we further clarify the role of NHERF1 in the regulation of CFTR activity in two human bronchial epithelial cell lines: the normal,...
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