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Article

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

Developmental cell - 26 Mar 2018

Okiyoneda Tsukasa, Veit Guido, Sakai Ryohei, Aki Misaki, Fujihara Takeshi, Higashi Momoko, Susuki-Miyata Seiko, Miyata Masanori, Fukuda Norihito, Yoshida Akihiko, Xu Haijin, Apaja Pirjo M, Lukacs Gergely L

Abstract excerpt

The peripheral protein quality control (QC) system removes non-native membrane proteins, including ΔF508-CFTR, the most common CFTR mutant in cystic fibrosis (CF), from the plasma membrane (PM) for lysosomal degradation by ubiquitination. It remains unclear how unfolded membrane proteins are recognized and targeted for ubiquitination and how they are removed from the apical PM. Using comprehensive siRNA screens,...

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Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Chaperones

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Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 29503157
DOI: 10.1016/j.devcel.2018.02.001
PMCID: PMC6447300

Genes

CFTR
RFFL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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