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Article

Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications

30 Jul 2016

Abstract excerpt

Posttranslational modifications add diversity to protein function. Throughout its life cycle, the cystic fibrosis transmembrane conductance regulator (CFTR) undergoes numerous covalent posttranslational modifications (PTMs), including glycosylation, ubiquitination, sumoylation, phosphorylation, and palmitoylation. These modifications regulate key steps during protein biogenesis, such as protein folding,...

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PMID: 27474090
DOI: 10.1152/ajplung.00431.2015

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