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Article

Effects of Pseudomonas aeruginosa on CFTR chloride secretion and the host immune response

26 Jan 2017

Abstract excerpt

In the healthy lung the opportunistic pathogen, Pseudomonas aeruginosa, is rapidly eliminated by mucociliary clearance, a process that is dependent on the activity of the CFTR anion channel that, in concert with a number of other transport proteins, regulates the volume and composition of the periciliary surface liquid. This fluid layer is essential to enable cilia to clear pathogens from the lungs. However, in...

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PMID: 28122735
DOI: 10.1152/ajpcell.00373.2016

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