Article
Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2004
Virella-Lowell Isabel, Herlihy John-David, Liu Barry, Lopez Cecilia, Cruz Pedro, Muller Chris, Baker Henry V, Flotte Terence R
Abstract excerpt
Mutations in CFTR lead to a complex phenotype that includes increased susceptibility to Pseudomonas infections, a functional deficiency of IL-10, and an exaggerated proinflammatory cytokine response. We examined the effects of CFTR gene correction on the gene expression profile of a CF bronchial epithelial cell line (IB3-1) and determined which CF-related gene expression changes could be reversed by IL-10...
Topics
- Animals
- Bronchi
- Cell Line
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Epithelial Cells
- Gene Expression Profiling
- Humans
- Interleukin-10
- Mutation
- Pseudomonas aeruginosa
- Respiratory Mucosa