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Article

Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications.

Protein engineering, design & selection : PEDS - 1 Jan 2012

McClure Michelle, DeLucas Lawrence J, Wilson Landon, Ray Marjorie, Rowe Steven M, Wu Xiaoyun, Dai Qun, Hong Jeong S, Sorscher Eric J, Kappes John C, Barnes Stephen

Abstract excerpt

Post-translational modifications (PTMs) play a crucial role during biogenesis of many transmembrane proteins. Previously, it had not been possible to evaluate PTMs in cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial ion channel responsible for cystic fibrosis, because of difficulty obtaining sufficient amounts of purified protein. We recently used an inducible overexpression strategy to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22119790
DOI: 10.1093/protein/gzr054
PMCID: PMC3276306

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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