Article
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.
The Journal of biological chemistry - 13 Jun 2003
Benharouga Mohamed, Sharma Manu, So Jeffry, Haardt Martin, Drzymala Luke, Popov Milka, Schwapach Blanche, Grinstein Sergio, Du Kai, Lukacs Gergely L
Abstract excerpt
The conserved C-terminal peptide motif (1476DTRL) of the cystic fibrosis transmembrane conductance regulator (CFTR) ensures high affinity binding to different PSD-95/Disc-large/zonula occludens-1 (PDZ) domain-containing molecules, including the Na+/H+ exchanger regulatory factor (NHERF)/ezrin-radixin-moesin-binding phosphoprotein of 50 kDa. The physiological relevance of NHERF binding to CFTR is not fully...
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