Article
Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.
Biology of the cell - 1 Jul 2008
Fanelli Teresa, Cardone Rosa Angela, Favia Maria, Guerra Lorenzo, Zaccolo Manuela, Monterisi Stefania, De Santis Teresa, Riccardi Stefania Maria, Reshkin Stephan Joel, Casavola Valeria
Abstract excerpt
BACKGROUND INFORMATION: CF (cystic fibrosis) is a disease caused by mutations within the CFTR (CF transmembrane conductance regulator) gene. The most common mutation, DeltaF508 (deletion of Phe-508), results in a protein that is defective in folding and trafficking to the cell surface but is functional if properly localized in the plasma membrane. We have recently demonstrated that overexpression of the PDZ...
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