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Article

The Role of Toll-Like Receptor Pathways in the Mechanism of Type 1 Diabetes

30 Jan 2009

Abstract excerpt

Toll-like receptors (TLRs) and the innate immune system play a key role in sensing and eliminating microbial infections. Interactions between TLRs and their ligands expressed by microbial pathogens induce a cascade of intracellular signaling events, culminating in the upregulation of proinflammatory pathways. Over the past two decades, numerous studies have established the role of the acquired immune system in...

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PMID: 19199942
DOI: 10.2174/156652409787314453

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