Article
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Immunity - 21 Mar 2013
Wies Effi, Wang May K, Maharaj Natalya P, Chen Kan, Zhou Shenghua, Finberg Robert W, Gack Michaela U
Abstract excerpt
RIG-I and MDA5 have emerged as key cytosolic sensors for the detection of RNA viruses and lead to antiviral interferon (IFN) production. Recent studies have highlighted the importance of posttranslational modifications for controlling RIG-I antiviral activity. However, the regulation of MDA5 signal-transducing ability remains unclear. Here, we show that MDA5 signaling activity is regulated by a dynamic balance...
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