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Article

Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998

van Meerwijk J P, Bianchi T, Marguerat S, MacDonald H R

Abstract excerpt

During their development, immature CD4+ CD8+ thymocytes become committed to either the CD4 or CD8 lineage. Subsequent complete maturation of CD4+ and CD8+ cells requires a molecular match of the expressed coreceptor and the MHC specificity of the TCR. The final size of the mature CD4+ and CD8+ th...

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PMID: 9558064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9558064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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